Glucose metabolism studied isotopically in diabetic dogs: Effect of restoration of peripheral normoinsulinaemia by the artificial B cell

@article{Freyse1983GlucoseMS,
  title={Glucose metabolism studied isotopically in diabetic dogs: Effect of restoration of peripheral normoinsulinaemia by the artificial B cell},
  author={E. -J. Freyse and Uwe Fischer and Guenther Albrecht},
  journal={Diabetologia},
  year={1983},
  volume={25},
  pages={411-417}
}
Normoglycaemia, peripheral normoinsulinaemia, and normoglucagonaemia were restored acutely in chronically diabetic dogs, using an extracorporal artificial B cell with peripheral venous insulin administration. Glucose metabolism was analysed by a non-steady-state tracer technique with double-labelled glucose (6-3H-and U-14C-glucose), and the incorporation of the 14C label into plasma lactate was determined. In the basal state, glucose turnover rates were not different from those in non-diabetic… CONTINUE READING
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