Glucose metabolism in the Belgrade rat, a model of iron-loading anemia.

@article{Jia2013GlucoseMI,
  title={Glucose metabolism in the Belgrade rat, a model of iron-loading anemia.},
  author={Xuming Jia and Jonghan Kim and Tania Veuthey and C H Lee and Marianne Wessling-Resnick},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2013},
  volume={304 12},
  pages={G1095-102}
}
The iron-diabetes hypothesis proposes an association between iron overload and glucose metabolism that is supported by a number of epidemiological studies. The prevalence of type 2 diabetes in patients with hereditary hemochromatosis and iron-loading thalassemia supports this hypothesis. The Belgrade rat carries a mutation in the iron transporter divalent metal transporter 1 (DMT1) resulting in iron-loading anemia. In this study, we characterized the glycometabolic status of the Belgrade rat… CONTINUE READING