Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter.

  title={Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter.},
  author={Darrell D. Belke and Terje S. Larsen and E. Michael Gibbs and David L. Severson},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={280 3},
  • D. BelkeT. Larsen D. Severson
  • Published 1 March 2001
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Glucose and fatty acid metabolism was assessed in isolated working hearts from control C57BL/KsJ-m+/+db mice and transgenic mice overexpressing the human GLUT-4 glucose transporter (db/+-hGLUT-4). Heart rate, coronary flow, cardiac output, and cardiac power did not differ between control hearts and hearts overexpressing GLUT-4. Hearts overexpressing GLUT-4 had significantly higher rates of glucose uptake and glycolysis and higher levels of glycogen after perfusion than control hearts, but rates… 

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