Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter.

@article{Belke2001GlucoseMI,
  title={Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter.},
  author={Darrell D. Belke and Terje Steinar Larsen and E. Michael Gibbs and David L. Severson},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={280 3},
  pages={E420-7}
}
Glucose and fatty acid metabolism was assessed in isolated working hearts from control C57BL/KsJ-m+/+db mice and transgenic mice overexpressing the human GLUT-4 glucose transporter (db/+-hGLUT-4). Heart rate, coronary flow, cardiac output, and cardiac power did not differ between control hearts and hearts overexpressing GLUT-4. Hearts overexpressing GLUT-4 had significantly higher rates of glucose uptake and glycolysis and higher levels of glycogen after perfusion than control hearts, but rates… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Diabetes impairs heart mitochondrial function without changes in resting cardiac performance.

The international journal of biochemistry & cell biology • 2016
View 1 Excerpt
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Fuels: aerobic and anaerobic metabolism

LH Opie
New York: Lippincott-Raven, • 1998
View 3 Excerpts
Highly Influenced

Ventricular energetics.

Physiological reviews • 1990
View 2 Excerpts
Highly Influenced

Glucose and fatty acid metabolism in the isolated working mouse heart.

American journal of physiology. Regulatory, integrative and comparative physiology • 1999
View 5 Excerpts

Heterozygosity for Lepob or Leprdb affects body composition and leptin homeostasis in adult mice.

American journal of physiology. Regulatory, integrative and comparative physiology • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…