Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival.

@article{MacIver2008GlucoseMI,
  title={Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival.},
  author={Nancie J MacIver and Sarah R. Jacobs and Heather L. Wieman and Jessica A. Wofford and Jonathan L. Coloff and Jeffrey C. Rathmell},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 4},
  pages={949-57}
}
Lymphocytes require glucose uptake and metabolism for normal survival and function. The signals that regulate the expression and localization of glucose transporter 1 (Glut1) to allow glucose uptake in T cells are now beginning to be understood. Resting T cells require extracellular signals, such as cytokines, hormones, and growth factors, or low-level TCR stimulation to take up adequate glucose to maintain housekeeping functions. In the absence of extrinsic signals, resting T cells internalize… CONTINUE READING
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