Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?

@article{Hoyer1988GlucoseMA,
  title={Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?},
  author={Siegfried Hoyer and K. Oesterreich and Oded Wagner},
  journal={Journal of Neurology},
  year={1988},
  volume={235},
  pages={143-148}
}
Global cerebral blood flow, oxidative brain metabolism, and the cerebral arteriovenous differences of amino acids and ammonia were studied in 20 clinically diagnosed patients with early-onset dementia of Alzheimer type (DAT). Eleven healthy age-matched subjects and 15 healthy young volunteers served as controls. The most prominent abnormality in patients with early-onset DAT was a 44% reduction in the cerebral metabolic rate of glucose and a fourfold increase of lactate production, whereas… CONTINUE READING

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