Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats

@article{Navarro2007GlucoseLP,
  title={Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats},
  author={D. Navarro and C. Zwingmann and N. Chatauret and R. Butterworth},
  journal={Metabolic Brain Disease},
  year={2007},
  volume={23},
  pages={115-122}
}
Glucose loading in thiamine-deficient patients is known to precipitate Wernicke’s Encephalopathy; however, the mechanisms responsible have not been fully elucidated. Lactate accumulation occurs in brains of thiamine-deficient rats. In order to determine whether glucose loading in thiamine-deficient rats causes selective lactic acidosis in vulnerable brain structures, cerebral pH was measured autoradiographically using 14-labeled 5,5-dimethyloxazolidine-2, 4-dione ([14C]DMO) in the medial… Expand
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