Glucose is required to maintain high ATP-levels for the energy-utilizing steps during PDT-induced apoptosis.

@article{Oberdanner2002GlucoseIR,
  title={Glucose is required to maintain high ATP-levels for the energy-utilizing steps during PDT-induced apoptosis.},
  author={Christian Benno Oberdanner and Tobias Kiesslich and Barbara Krammer and Kristjan Plaetzer},
  journal={Photochemistry and photobiology},
  year={2002},
  volume={76 6},
  pages={
          695-703
        }
}
Photodynamic therapy (PDT) may trigger apoptosis or necrosis in cancer cells. Several steps in the induction and execution of apoptosis require high amounts of adenosine-5'-triphosphate (ATP). Because the mitochondrial membrane potential (delta psi) decreases early in apoptosis, we raised the question about the mechanisms of maintaining a sufficiently high ATP level. We therefore monitored delta psi and the intracellular ATP level of apoptotic human epidermoid carcinoma cells (A431) after… CONTINUE READING

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