Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas.

@article{Giroix1983GlucoseIA,
  title={Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas.},
  author={M. H. Giroix and Bernard Portha and Micheline Kergoat and Dani{\`e}le Bailb{\'e} and Luc Picon},
  journal={Diabetes},
  year={1983},
  volume={32 5},
  pages={445-51}
}
Non-insulin-dependent diabetes (NIDDM) was obtained in adult rats following a neonatal streptozotocin injection. Rats with NIDDM exhibited slightly lowered plasma insulin, slightly elevated basal plasma glucose values (less than 200 mg/dl), and low pancreatic insulin stores (50% of the controls). Insulin secretion was studied in this model using the isolated perfused pancreas technique. Insulin response to glucose stimulation over the range 5.5-22 mM was lacking, thus indicating complete loss… CONTINUE READING

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