Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

@article{Rorsman1989GlucoseinhibitionOG,
  title={Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels},
  author={Patrik Rorsman and P O Berggren and Krister B. Bokvist and Hans Ericson and Hanns M{\"o}hler and Claes-G{\"o}ran {\"O}stenson and Paul A. Smith},
  journal={Nature},
  year={1989},
  volume={341},
  pages={233-236}
}
THE endocrine part of the pancreas plays a central role in blood-glucose regulation. It is well established that an elevation of glucose concentration reduces secretion of the hyperglycaemia-associated hormone glucagon from pancreatic α2 cells. The mechanisms involved, however, remain unknown. Electrophysio-logical studies have demonstrated that α2 cells generate Ca2+-dependent action potentials. The frequency of these action poten-tials, which increases under conditions that stimulate glucagon… Expand
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