Glucose induces opposite intracellular Ca2+ concentration oscillatory patterns in identified alpha- and beta-cells within intact human islets of Langerhans.

@article{Quesada2006GlucoseIO,
  title={Glucose induces opposite intracellular Ca2+ concentration oscillatory patterns in identified alpha- and beta-cells within intact human islets of Langerhans.},
  author={Iv{\'a}n Quesada and Mariana G Todorova and Paloma Alonso-Magdalena and Marta Beltr{\'a} and Everardo Magalh{\~a}es Carneiro and Franz Mart{\'i}n and Angel Nadal and Bernat Soria},
  journal={Diabetes},
  year={2006},
  volume={55 9},
  pages={2463-9}
}
Homeostasis of blood glucose is mainly regulated by the coordinated secretion of glucagon and insulin from alpha- and beta-cells within the islets of Langerhans. The release of both hormones is Ca(2+) dependent. In the current study, we used confocal microscopy and immunocytochemistry to unequivocally characterize the glucose-induced Ca(2+) signals in alpha- and beta-cells within intact human islets. Extracellular glucose stimulation induced an opposite response in these two cell types… CONTINUE READING

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