Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.

Abstract

In autoimmune type 1 diabetes, Fas-to-Fas-ligand (FasL) interaction may represent one of the essential pro-apoptotic pathways leading to a loss of pancreatic beta-cells. In the advanced stages of type 2 diabetes, a decline in beta-cell mass is also observed, but its mechanism is not known. Human islets normally express FasL but not the Fas receptor. We… (More)

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Cite this paper

@article{Maedler2001GlucoseIB, title={Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.}, author={Kathrin Maedler and Giatgen Spinas and R. Lehmann and Pavel Sergeev and M. Weber and Andrea Fontana and Norbert Kaiser and Max Donath}, journal={Diabetes}, year={2001}, volume={50 8}, pages={1683-90} }