Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines

Abstract

The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated β-catenin degradation. This results in the accumulation and subsequent nuclear translocation of β-catenin, which induces the expression of a number of genes involved in growth, differentiation and metabolism. The mechanisms regulating the Wnt signalling pathway in the… (More)

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@inproceedings{Anagnostou2008GlucoseIA, title={Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines}, author={Sasha H Anagnostou and Peter R. Shepherd}, year={2008} }