Glucose-induced suppression of endogenous glucose production: dynamic response to differing glucose profiles.

@article{Vella2003GlucoseinducedSO,
  title={Glucose-induced suppression of endogenous glucose production: dynamic response to differing glucose profiles.},
  author={Adrian Vella and Ann S Reed and Nisha Charkoudian and Pankaj Shah and Rita Basu and Ananda Basu and Michael J. Joyner and Robert A. Rizza},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 1},
  pages={E25-30}
}
To determine whether, in the presence of constant insulin concentrations, a change in glucose concentrations results in a reciprocal change in endogenous glucose production (EGP), glucagon ( approximately 130 ng/l) and insulin ( approximately 65 pmol/l) were maintained at constant "basal" concentrations while glucose was clamped at approximately 5.3 mM (euglycemia), approximately 7.0 mM (sustained hyperglycemia; n = 10), or varied to create a "postprandial" profile (profile; n = 11). EGP fell… CONTINUE READING

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