Glucose-induced islet hyperemia is mediated by nitric oxide.

  title={Glucose-induced islet hyperemia is mediated by nitric oxide.},
  author={Stephen Moldovan and Elizabeth R. Livingston and R. D. Zhang and Richard G. Kleinman and Paul Guth and F. Charles Brunicardi},
  journal={American journal of surgery},
  volume={171 1},
PURPOSE To determine whether hyperglycemia affects pancreatic islet microcirculation in vivo and whether nitric oxide is a mediator. METHODS Islet blood flow was measured before and after infusion of glucose during in vivo microscopy of mouse pancreatic islet. The pancreas of male BALB/c mice was exteriorized and viewed under the microscope utilizing monochromatic transmitted light. The carotid artery and tail vein were cannulated and systemic blood pressure was monitored continuously. Under… CONTINUE READING
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