Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase.

@article{Mbonyi1990GlucoseinducedHO,
  title={Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase.},
  author={Kaishusha Mbonyi and Linda Van Aelst and Juan Carlos Arg{\"u}elles and Arnold W. H. Jans and Johan M Thevelein},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 9},
  pages={4518-23}
}
Addition of glucose or related fermentable sugars to derepressed cells of the yeast Saccharomyces cerevisiae triggers a RAS-mediated cyclic AMP (cAMP) signal that induces a protein phosphorylation cascade. In yeast mutants (tpk1w1, tpk2w1, and tpk3w1) containing reduced activity of cAMP-dependent protein kinase, fermentable sugars, as opposed to nonfermentable carbon sources, induced a permanent hyperaccumulation of cAMP. This finding confirms previous conclusions that fermentable sugars are… CONTINUE READING

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