Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization.

@article{Wang2010GlucoseinducedEH,
  title={Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization.},
  author={Fang Wang and Ying Wang and Min Suk Kim and Prasanth Puthanveetil and Sanjoy Ghosh and Dan S. Luciani and James D Johnson and Ashraf Abrahani and Brian Rodrigues},
  journal={Cardiovascular research},
  year={2010},
  volume={87 1},
  pages={127-36}
}
AIMS Heparanase, which specifically cleaves carbohydrate chains of heparan sulfate, has been implicated in the pathology of diabetes-associated complications. Using high glucose (HG) to replicate hyperglycaemia observed following diabetes, the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion. METHOD AND RESULTS To examine the effect of HG on endothelial heparanase, bovine coronary artery endothelial cells were incubated with 25 mM… CONTINUE READING

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In endothelial cells , heparanase colocalized with lysosomes predominately around the nucleus , and HG caused its dispersion towards the plasma membrane for subsequent secretion .
In endothelial cells , heparanase colocalized with lysosomes predominately around the nucleus , and HG caused its dispersion towards the plasma membrane for subsequent secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
GlucoseContraindicated with diseaseHyperglycemia
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
Using high glucose ( HG ) to replicate hyperglycaemia observed following diabetes , the present study was designed to determine the mechanism by which HG initiates endothelial heparanase secretion .
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