Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

@article{Tang2012GlucoseinducedBC,
  title={Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress},
  author={Chaoshu Tang and Khajag B Koulajian and Irmgard Schuiki and Lian Zhang and Tejas Desai and Aleksandar Ivovic and Pei Wang and Christine A. Robson-Doucette and Michael B Wheeler and Beatrice F Minassian and Allen Volchuk and Adria Giacca},
  journal={Diabetologia},
  year={2012},
  volume={55},
  pages={1366-1379}
}
Endoplasmic reticulum (ER) stress has been implicated in glucose-induced beta cell dysfunction. However, its causal role has not been established in vivo. Our objective was to determine the causal role of ER stress and its link to oxidative stress in glucose-induced beta cell dysfunction in vivo. Healthy Wistar rats were infused i.v. with glucose for 48 h to achieve 20 mmol/l hyperglycaemia with or without the co-infusion of the superoxide dismutase mimetic tempol (TPO), or the chemical… CONTINUE READING
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