Glucose-induced ERM protein activation and translocation regulates insulin secretion.

  title={Glucose-induced ERM protein activation and translocation regulates insulin secretion.},
  author={James P. Lopez and Jerrold R Turner and Louis Philipson},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={299 5},
A key step in regulating insulin secretion is insulin granule trafficking to the plasma membrane. Using live-cell time-lapse confocal microscopy, we observed a dynamic association of insulin granules with filamentous actin and PIP2-enriched structures. We found that the scaffolding protein family ERM, comprising ezrin, radixin, and moesin, are expressed in β-cells and target both F-actin and PIP2. Furthermore, ERM proteins are activated via phosphorylation in a glucose- and calcium-dependent… CONTINUE READING


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