Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.

@article{Lakhter2016GlucoseindependentAM,
  title={Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.},
  author={Alexander J. Lakhter and James Hamilton and Raymond L. Konger and Nickolay Brustovetsky and Hal E. Broxmeyer and Samisubbu R Naidu},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 42},
  pages={21869-21879}
}
Tumors rely on multiple nutrients to meet cellular bioenergetics and macromolecular synthesis demands of rapidly dividing cells. Although the role of glucose and glutamine in cancer metabolism is well understood, the relative contribution of acetate metabolism remains to be clarified. We show that glutamine supplementation is not sufficient to prevent loss of cell viability in a subset of glucose-deprived melanoma cells, but synergizes with acetate to support cell survival. Glucose-deprived… CONTINUE READING