Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels.

@article{Orellana2012GlucoseII,
  title={Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels.},
  author={Juan Andr{\'e}s Orellana and Pablo J S{\'a}ez and Christian Cort{\'e}s-Campos and Roberto J Elizondo and Kenji F Shoji and Susana Contreras-Duarte and Vania A. Figueroa and Victoria Velarde and Jean X Jiang and Francisco Nualart and Juan C S{\'a}ez and Mar{\'i}a de los Angeles Garc{\'i}a},
  journal={Glia},
  year={2012},
  volume={60 1},
  pages={53-68}
}
The ventromedial hypothalamus is involved in regulating feeding and satiety behavior, and its neurons interact with specialized ependymal-glial cells, termed tanycytes. The latter express glucose-sensing proteins, including glucose transporter 2, glucokinase, and ATP-sensitive K(+) (K(ATP) ) channels, suggesting their involvement in hypothalamic glucosensing. Here, the transduction mechanism involved in the glucose-induced rise of intracellular free Ca(2+) concentration ([Ca(2+) ](i) ) in… CONTINUE READING
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