Glucose enhancement of LDL oxidation is strictly metal ion dependent.

@article{Mowri2000GlucoseEO,
  title={Glucose enhancement of LDL oxidation is strictly metal ion dependent.},
  author={H. Mowri and B. Frei and J. Keaney},
  journal={Free radical biology & medicine},
  year={2000},
  volume={29 9},
  pages={
          814-24
        }
}
  • H. Mowri, B. Frei, J. Keaney
  • Published 2000
  • Chemistry, Medicine
  • Free radical biology & medicine
  • Recent evidence suggests that lipoprotein oxidation is increased in diabetes, however, the mechanism(s) for such observations are not clear. We examined the effect of glucose on low-density lipoprotein (LDL) oxidation using metal ion-dependent and -independent oxidation systems. Pathophysiological concentrations of glucose (25 mM) enhanced copper-induced LDL oxidation as determined by conjugated diene formation or relative electrophoretic mobility (REM) on agarose gels. Similarly, iron-induced… CONTINUE READING

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