Glucose effectiveness is the major determinant of intravenous glucose tolerance in the rat.

@article{McArthur1999GlucoseEI,
  title={Glucose effectiveness is the major determinant of intravenous glucose tolerance in the rat.},
  author={Marion McArthur and Dan You and Kim Klapstein and Diane T. Finegood},
  journal={The American journal of physiology},
  year={1999},
  volume={276 4 Pt 1},
  pages={E739-46}
}
To determine the importance of insulin for glucose disposal during an intravenous glucose tolerance test in rats, experiments were performed in four cohorts of conscious unrestrained rats fasted overnight. In cohorts 1- 3, a bolus of tracer ([3-3H]glucose, 50 μCi) was given alone, with glucose (0.3 g/kg) to induce an endogenous insulin response (∼1,100 pmol/l), or with exogenous insulin to give physiological (1,700 pmol/l) or supraphysiological (12,000 pmol/l) plasma levels. Raising plasma… CONTINUE READING