Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species.

@article{Liu2007GlucoseDO,
  title={Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species.},
  author={Shu Liu and Xueying Ma and Mingcui Gong and L. Shi and T. Lincoln and S. Wang},
  journal={Free radical biology & medicine},
  year={2007},
  volume={42 6},
  pages={
          852-63
        }
}
  • Shu Liu, Xueying Ma, +3 authors S. Wang
  • Published 2007
  • Medicine, Chemistry
  • Free radical biology & medicine
  • Reduced levels of cGMP-dependent protein kinase I (PKG-I) in vasculature have been shown to contribute to diabetic vascular dysfunctions. However, the underlying mechanisms remain unknown. In this report, using primary rat aortic smooth muscle cells (VSMC), we investigated the mechanisms of glucose-mediated regulation of PKG-I expression. Our data showed that high glucose (30 mM glucose) exposure significantly reduced PKG-I production (protein and mRNA levels) as well as PKG-I activity in… CONTINUE READING

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