Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response.

@article{Chang2002GlucoseDI,
  title={Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response.},
  author={S Chang and Ione P Barbosa-Tessmann and Chin Fong Chen and Michael S. Kilberg and Anupam Agarwal},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 3},
  pages={1933-40}
}
Nutrients such as glucose regulate the expression of genes that are involved in plasma membrane transport, metabolic functions, and protein trafficking in the endoplasmic reticulum. Depletion of nutrients results in cellular stress, which evokes adaptive and protective responses, one of which is the induction of heme oxygenase-1 (HO-1), a 32-kDa endoplasmic reticulum enzyme that catalyzes the rate-limiting step in heme degradation. Incubation of HepG2 human hepatoma cells in glucose-free medium… CONTINUE READING

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