Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells

@article{CaroMaldonado2010GlucoseDI,
  title={Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells},
  author={Alfredo Caro-Maldonado and Stephen W G Tait and Silvia Ram{\'i}rez-Peinado and J E Ricci and Isabel Fabregat and Douglas R Green and Cristina Mu{\~n}oz-Pinedo},
  journal={Cell Death and Differentiation},
  year={2010},
  volume={17},
  pages={1335-1344}
}
Apoptosis induced by most stimuli proceeds through the mitochondrial pathway. One such stimulus is nutrient deprivation. In this study we studied death induced by glucose deprivation in cells deficient in Bax and Bak. These cells cannot undergo mitochondrial outer membrane permeabilization (MOMP) during apoptosis, but they undergo necrosis when treated with… CONTINUE READING