Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

@article{Kelley2009GlucosedependentPO,
  title={Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.},
  author={Grant G. Kelley and Oleg G. Chepurny and Frank Schwede and Hans-G Genieser and Colin A Leech and Michael W. Roe and Xiangquan Li and Igor Dzhura and Elvira V Dzhura and Parisa Afshari and George G. Holz},
  journal={Islets},
  year={2009},
  volume={1 3},
  pages={260-5}
}
Epac2 is a cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) that is proposed to mediate stimulatory actions of the second messenger cAMP on mouse islet insulin secretion. Here we have used methods of islet perifusion to demonstrate that the acetoxymethyl ester (AM-ester) of an Epac-selective cAMP analog (ESCA) penetrates into mouse islets and is… CONTINUE READING