Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling.

@article{Truemper2001GlucosedependentIP,
  title={Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling.},
  author={Andreas Truemper and Katja Tr{\"u}mper and Heidi Trusheim and Ralf Arnold and Burkhard J. G{\"o}ke and Dieter Hoersch},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 9},
  pages={1559-70}
}
Activation of the G-protein-coupled receptor for glucose-dependent insulinotropic polypeptide facilitates insulin-release from pancreatic beta-cells. In the present study, we examined whether glucose-dependent insulinotropic polypeptide also acts as a growth factor for the beta-cell line INS-1. Here, we show that glucose-dependent insulinotropic polypeptide induced cellular proliferation synergistically with glucose between 2.5 mM and 15 mM by pleiotropic activation of signaling pathways… CONTINUE READING
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Differential activation of PKB and p 70 S 6 K by glucose and IGF - 1 in pancreatic  - cells ( INS - 1 )

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