Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum.

@article{Coon2013GlucosedependentIP,
  title={Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum.},
  author={Steven D. Coon and John H. Schwartz and Vazhaikkurichi M. Rajendran and Lisa I Jepeal and Satish Kumar Singh},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2013},
  volume={305 10},
  pages={G678-84}
}
Glucose-dependent insulinotropic polypeptide (GIP) secreted from jejunal mucosal K cells augments insulin secretion and plays a critical role in the pathogenesis of obesity and Type 2 diabetes mellitus. In recent studies, we have shown GIP directly activates Na-glucose cotransporter-1 (SGLT1) and enhances glucose absorption in mouse jejunum. It is not known whether GIP would also regulate other intestinal nutrient absorptive processes. The present study investigated the effect of GIP on proton… CONTINUE READING
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GIP activation of signaling pathways traffics Pept1 to the apical membrane of intestinal epithelial cells

  • S Coon, JH Schwartz, SK. Singh
  • Gastroenterology 144:
  • 2013
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