Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds.

@article{Bleck2004GlucoseDO,
  title={Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds.},
  author={Claudia Bleck and Antje Wienbergen and Ingo Rustenbeck},
  journal={Diabetes},
  year={2004},
  volume={53 Suppl 3},
  pages={S135-9}
}
The glucose dependence of the insulinotropic action of KATP channel-blocking imidazoline compounds was investigated. Administration of 100 micromol/l phentolamine, but not 100 micromol/l efaroxan, markedly increased insulin secretion of freshly isolated mouse islets when the perifusion medium contained 5 mmol/l glucose. When the glucose concentration was… CONTINUE READING