Glucose-containing peritoneal dialysis fluids regulate leptin secretion from 3T3-L1 adipocytes.

@article{Teta2005GlucosecontainingPD,
  title={Glucose-containing peritoneal dialysis fluids regulate leptin secretion from 3T3-L1 adipocytes.},
  author={Daniel Teta and A. Tedjani and Michel Burnier and Alan Bevington and Jeremy R. Glissen Brown and Kevin P. G. Harris},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2005},
  volume={20 7},
  pages={
          1329-35
        }
}
  • D. Teta, A. Tedjani, +3 authors K. Harris
  • Published 2005
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND A marked elevation of serum leptin is observed soon after the start of peritoneal dialysis (PD), suggesting that leptin production may be stimulated by this treatment. Glucose metabolism is the major factor regulating leptin. The current study was designed to test if glucose-based PD fluids might regulate leptin production in vitro. METHODS 3T3-L1 adipocytes were exposed to a 50:50 mixture of dialysis solutions and medium M199 containing 10% serum for <or=48 h. Leptin secretion in… Expand
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3 Membrane Biology During Peritoneal Dialysis
Peritoneal dialysis (PD) is a life-supporting renal replacement therapy used by 10-15% of patients with end-stage renal failure worldwide. The success of long-term PD depends entirely on theExpand
Impact of Glucose in Peritoneal Dialysis: Saint or Sinner?
  • T. Sitter, M. Sauter
  • Medicine
  • Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
  • 2005
TLDR
Adverse effects of glucose in PD solutions are focused on, different aspects of glucotoxicity and potential therapeutic interventions are summarized, and new approaches to the problem of glucose-related toxicity have been made. Expand
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