Glucose clamp technique: a method for quantifying insulin secretion and resistance.

@article{DeFronzo1979GlucoseCT,
  title={Glucose clamp technique: a method for quantifying insulin secretion and resistance.},
  author={Ralph A. DeFronzo and Jordan D. Tobin and Reubin Andres},
  journal={The American journal of physiology},
  year={1979},
  volume={237 3},
  pages={
          E214-23
        }
}
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described. [] Key Method Hyperglycemic clamp technique. The plasma glucose concentration is acutely raised to 125 mg/dl above basal levels by a priming infusion of glucose. The desired hyperglycemic plateau is subsequently maintained by adjustment of a variable glucose infusion, based on the negative feedback principle. Because the…

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