Glucose-based peritoneal dialysis fluids downregulate toll-like receptors and trigger hyporesponsiveness to pathogen-associated molecular patterns in human peritoneal mesothelial cells.

@article{Wu2010GlucosebasedPD,
  title={Glucose-based peritoneal dialysis fluids downregulate toll-like receptors and trigger hyporesponsiveness to pathogen-associated molecular patterns in human peritoneal mesothelial cells.},
  author={J Wu and Xiao Yang and Yun-fang Zhang and Ya-Ning Wang and Mei Liu and Xiu-qing Dong and Jin-jin Fan and Xue-qing Yu},
  journal={Clinical and vaccine immunology : CVI},
  year={2010},
  volume={17 5},
  pages={757-63}
}
The objective of this study was to investigate the effects of glucose-based peritoneal dialysis (PD) fluids and icodextrin-based PD fluids on the expression of Toll-like receptor 2 (TLR2)/TLR4 and subsequent ligand-induced mitogen-activated protein kinase (MAPK) and NF-kappaB signaling and tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expression in human peritoneal mesothelial cells (HPMCs). A human peritoneal mesothelial cell line (HMrSV5) was stimulated with… CONTINUE READING