Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.

@article{Li2012GlucoseAI,
  title={Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.},
  author={Tiangang Li and Jessica M. Francl and Shannon Boehme and Adri{\'a}n Zolano Ochoa and Youcai Zhang and Curtis Dean Klaassen and Sandra K. Erickson and John Y. L. Chiang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 3},
  pages={
          1861-73
        }
}
Bile acids facilitate postprandial absorption of nutrients. Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 and play a major role in regulating lipid, glucose, and energy metabolism. Transgenic expression of cholesterol 7α-hydroxylase (CYP7A1) prevented high fat diet-induced diabetes and obesity in mice. In this study, we investigated the nutrient effects on bile acid synthesis. Refeeding of a chow diet to fasted mice increased CYP7A1 expression… CONTINUE READING
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