Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium.

@article{Bowden2009GlucoseAG,
  title={Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium.},
  author={Steven D. Bowden and Gary Rowley and Jay C. D. Hinton and Arthur Septimus Thompson},
  journal={Infection and immunity},
  year={2009},
  volume={77 7},
  pages={3117-26}
}
Salmonella is a widespread zoonotic enteropathogen that causes gastroenteritis and fatal typhoidal disease in mammals. During systemic infection of mice, Salmonella enterica serovar Typhimurium resides and replicates in macrophages within the "Salmonella-containing vacuole" (SCV). It is surprising that the substrates and metabolic pathways necessary for growth of S. Typhimurium within the SCV of macrophages have not been identified yet. To determine whether S. Typhimurium utilized sugars within… CONTINUE READING