Glucose and citrate reduce the permeability changes caused by indomethacin in humans.

@article{Bjarnason1992GlucoseAC,
  title={Glucose and citrate reduce the permeability changes caused by indomethacin in humans.},
  author={Ingvar Bjarnason and Peter Smethurst and Allen Macpherson and Francine Walker and James C McElnay and Anthony Peter Passmore and Ian S. Menzies},
  journal={Gastroenterology},
  year={1992},
  volume={102 5},
  pages={1546-50}
}
Nonsteroidal anti-inflammatory drug (NSAID)-induced increased intestinal permeability appears to be a prerequisite for NSAID enteropathy. It has been suggested that early metabolic events leading to the permeability changes may involve inhibition of glycolysis and the tricarboxylic acid cycle, in which case the coadministration of glucose and citrate (the substrates for these metabolic pathways) with indomethacin may afford some protection. The present study, using a combined intestinal… CONTINUE READING

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