Glucose and alpha-ketoisocaproate induce transient inward currents in rat pancreatic beta cells.

@article{Best1997GlucoseAA,
  title={Glucose and alpha-ketoisocaproate induce transient inward currents in rat pancreatic beta cells.},
  author={Like Best},
  journal={Diabetologia},
  year={1997},
  volume={40 1},
  pages={1-6}
}
The perforated patch technique was used to study changes in membrane potential and whole-cell currents in single isolated rat pancreatic beta-cells during stimulation with glucose or alpha-ketoisocaproate. Increasing the glucose concentration from 4 to 20 mmol/l, or addition of 15 mmol/l alpha-ketoisocaproate, caused depolarization and, in most cases, initiation of action potentials. Under voltage-clamp conditions close to a potassium equilibrium potential (EK) (-60 to -70 mV) these effects… CONTINUE READING
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