Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation

@inproceedings{Snider2013GlucoseAS,
  title={Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation},
  author={Natasha T Snider and Jessica M. Leonard and Raymond Kwan and Nicholas W. Griggs and Liangyou Rui and M. Bishr Omary},
  booktitle={The Journal of cell biology},
  year={2013}
}
Lysine acetylation is an important posttranslational modification that regulates microtubules and microfilaments, but its effects on intermediate filament proteins (IFs) are unknown. We investigated the regulation of keratin 8 (K8), a type II simple epithelial IF, by lysine acetylation. K8 was basally acetylated and the highly conserved Lys-207 was a major acetylation site. K8 acetylation regulated filament organization and decreased keratin solubility. Acetylation of K8 was rapidly responsive… CONTINUE READING

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