Glucose alters the susceptibility of mesangial cells to contrast media.

Abstract

RATIONALE AND OBJECTIVES Diabetic patients frequently suffer contrast media-induced nephropathy. Hyperglycemia in diabetes mellitus causes gradual deterioration of glomerular mesangial cells (MCs) in the kidney. In this study, the authors investigated the response of rat MCs cultured in high-glucose medium to diatrizoate and iohexol, high- and low-osmolar… (More)

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