Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes

@article{Qiu2018GlucoseSI,
  title={Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes},
  author={Yijian Qiu and Jillian E. Milanes and Jessica A. Jones and Rooksana E Noorai and Vijay Shankar and James C. Morris},
  journal={mSphere},
  year={2018},
  volume={3}
}
As the African trypanosome Trypanosoma brucei completes its life cycle, it encounters many different environments. Adaptation to these environments includes modulation of metabolic pathways to parallel the availability of nutrients. Here, we describe how the blood-dwelling life cycle stages of the African trypanosome, which consume glucose to meet their nutritional needs, respond differently to culture in the near absence of glucose. The proliferative long slender parasites rapidly die, while… 
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TLDR
A genome-wide RNA-interference library screen for cell cycle regulators in bloodstream form Trypanosoma brucei is described, which facilitates functional annotation and drug-target prioritisation and provides comprehensive functional genomic evidence for the machineries, pathways and regulators that coordinate progression through the trypanosome cell cycle.
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TLDR
This review discusses the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly, and compares Trypanosoma brucei and TrypanOSoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms.
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