Glucose Metabolism in Breast Cancer and Its Implication in Cancer Therapy

  title={Glucose Metabolism in Breast Cancer and Its Implication in Cancer Therapy},
  author={Ning Li and Wen Tan and Jing Rong Li and Ping Li and Simon D Lee and Yitao Wang and Yuewen Gong},
It is well known that malignant cells have accelerated glucose uptake and metabolism in order to maintain their fast proliferation rates. With the increased influx of glucose into cancer cells, glycolysis is facilitated through a coordinated regulation of metabolic enzymes and pyruvate consumption. Shiftting from mitochondrial oxidative phosphorylation to glycolysis and other pathways such as pentose phosphate pathway (PPP) and de novo fatty acid synthesis in the breast tumor provides not only… CONTINUE READING


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