Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions

Abstract

While environmental exposures are not the single cause of Parkinson’s disease (PD), their interaction with genetic alterations is thought to contribute to neuronal dopaminergic degeneration. However, the mechanisms involved in dopaminergic cell death induced by gene-environment interactions remain unclear. In this work, we have revealed for the first time… (More)
DOI: 10.1007/s12035-016-9906-2

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@article{Anandhan2016GlucoseMA, title={Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions}, author={Annadurai Anandhan and Shulei Lei and Roman M. Levytskyy and Aglaia Pappa and Mihalis I. Panayiotidis and Ronald L. Cerny and Oleh Khalimonchuk and Robert Powers and R Franco}, journal={Molecular Neurobiology}, year={2016}, volume={54}, pages={3825-3842} }