Glucose Loading Precipitates Acute Encephalopathy in Thiamin-Deficient Rats

@article{Zimitat2004GlucoseLP,
  title={Glucose Loading Precipitates Acute Encephalopathy in Thiamin-Deficient Rats},
  author={C. Zimitat and P. Nixon},
  journal={Metabolic Brain Disease},
  year={2004},
  volume={14},
  pages={1-20}
}
A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete control and TD rats were assessed by scoring of clinical observations and performance measured on a moving belt (MB) apparatus at 30 min intervals for 2 hr after the challenge… Expand
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