Glucose Limitation Induces GCN4Translation by Activation of Gcn2 Protein Kinase

@article{Yang2000GlucoseLI,
  title={Glucose Limitation Induces GCN4Translation by Activation of Gcn2 Protein Kinase},
  author={Ruojing Yang and Sheree A. Wek and Ronald C Wek},
  journal={Molecular and Cellular Biology},
  year={2000},
  volume={20},
  pages={2706 - 2717}
}
  • Ruojing Yang, S. A. Wek, R. Wek
  • Published 2000
  • Medicine, Biology
  • Molecular and Cellular Biology
ABSTRACT Phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF-2α) is a well-characterized mechanism regulating protein synthesis in response to environmental stresses. In the yeastSaccharomyces cerevisiae, starvation for amino acids induces phosphorylation of eIF-2α by Gcn2 protein kinase, leading to elevated translation of GCN4, a transcriptional activator of more than 50 genes. Uncharged tRNA that accumulates during amino acid limitation is proposed to activate Gcn2p by… Expand
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  • Medicine, Biology
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