Glucose-Insulin-Potassium Reduces Infarct Size When Administered During Reperfusion

  title={Glucose-Insulin-Potassium Reduces Infarct Size When Administered During Reperfusion},
  author={Anne Kristine Jonassen and Ellen Aasum and Rudolph A. Riemersma and Ole D. Mj\os and Terje Steinar Larsen},
  journal={Cardiovascular Drugs and Therapy},
Coronary reperfusion improves ventricular function and survival after infarction, but the metabolic conditions at this time may not be optimal to protect the heart. The objective of this study was to evaluate if metabolic support with glucose-insulin-potassium (GIK) administered at the time of coronary reperfusion could elicit the same cardioprotection as GIK infusion during the entire ischemia/reperfusion period. Three groups of anesthetized, open-chest rats were subjected to 30 minutes of… CONTINUE READING