Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways

@inproceedings{Pezzulo2011GlucoseDI,
  title={Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways},
  author={Alejandro A. Pezzulo and Jeydith A Gutierrez and Kelly S. Duschner and Kelly S. McConnell and Peter J. Taft and Sarah E. Ernst and Timothy L. Yahr and Kamal Rahmouni and Julia Klesney-Tait and David A. Stoltz and Joseph Zabner},
  booktitle={PloS one},
  year={2011}
}
Diabetes mellitus predisposes the host to bacterial infections. Moreover, hyperglycemia has been shown to be an independent risk factor for respiratory infections. The luminal surface of airway epithelia is covered by a thin layer of airway surface liquid (ASL) and is normally sterile despite constant exposure to bacteria. The balance between bacterial growth and killing in the airway determines the outcome of exposure to inhaled or aspirated bacteria: infection or sterility. We hypothesized… CONTINUE READING
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