Glucose-6-phosphate dehydrogenase regulation during hypometabolism.

  title={Glucose-6-phosphate dehydrogenase regulation during hypometabolism.},
  author={Christopher J Ramnanan and Kenneth B. Storey},
  journal={Biochemical and biophysical research communications},
  volume={339 1},
Glucose-6-phosphate dehydrogenase (G6PDH) from hepatopancreas of the land snail, Otala lactea, shows distinct changes in properties between active and estivating (dormant) states, providing the first evidence of pentose phosphate cycle regulation during hypometabolism. Compared with active snails, G6PDH Vmax increased by 50%, Km for glucose-6-phosphate decreased by 50%, Ka Mg x citrate decreased by 35%, and activation energy (from Arrhenius plots) decreased by 35% during estivation. DEAE… CONTINUE READING