Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.

@article{Gupte2006Glucose6phosphateDN,
  title={Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.},
  author={Sachin A. Gupte and Robert J. Levine and Rakhee S Gupte and Martin Elliot Young and Vincenzo Lionetti and Volodymyr Labinskyy and Beverly C Floyd and Caroline Ojaimi and Michelle Bellomo and Michael S. Wolin and Fabio A. Recchia},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={41 2},
  pages={340-9}
}
In the failing heart, NADPH oxidase and uncoupled NO synthase utilize cytosolic NADPH to form superoxide. NADPH is supplied principally by the pentose phosphate pathway, whose rate-limiting enzyme is glucose 6-phosphate dehydrogenase (G6PD). Therefore, we hypothesized that cardiac G6PD activation drives part of the excessive superoxide production implicated in the pathogenesis of heart failure. Pacing-induced heart failure was performed in eight chronically instrumented dogs. Seven normal dogs… CONTINUE READING

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