Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.

  title={Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.},
  author={Sachin A. Gupte and Robert J. Levine and Rakhee S Gupte and Martin Elliot Young and Vincenzo Lionetti and Volodymyr Labinskyy and Beverly C Floyd and Caroline Ojaimi and Michelle Bellomo and Michael S. Wolin and Fabio A. Recchia},
  journal={Journal of molecular and cellular cardiology},
  volume={41 2},
In the failing heart, NADPH oxidase and uncoupled NO synthase utilize cytosolic NADPH to form superoxide. NADPH is supplied principally by the pentose phosphate pathway, whose rate-limiting enzyme is glucose 6-phosphate dehydrogenase (G6PD). Therefore, we hypothesized that cardiac G6PD activation drives part of the excessive superoxide production implicated in the pathogenesis of heart failure. Pacing-induced heart failure was performed in eight chronically instrumented dogs. Seven normal dogs… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 54 extracted citations


Publications referenced by this paper.
Showing 1-10 of 40 references

Increased myocardial NADPH oxidase activity in human heart failure.

Journal of the American College of Cardiology • 2003
View 6 Excerpts
Highly Influenced

Mitochondrial dysfunction in cardiovascular disease.

Free radical biology & medicine • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…