Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.

  title={Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.},
  author={John N. Clore and Josh Stillman and H Sugerman},
  volume={49 6},
Despite the effects of hyperinsulinemia and hyperglycemia, 2 factors known to inhibit endogenous glucose production (EGP) in nondiabetic subjects, increased EGP is a consistent feature of type 2 diabetes. Recent studies have suggested that increased glucose-6-phosphatase (G6Pase) and/or decreased glucokinase (GK) may explain the increase in EGP. However, no studies to date have clearly established this relationship in type 2 diabetes. The present studies were designed to determine rates of EGP… CONTINUE READING
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Insulin effects on substrate metabolism

  • WG Blackard, JN Clore
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