Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling


Glucose- or insulin resistance-mediated β-cell replication serves as a useful physiological model of β-cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β-cell proliferation induced by glucose stimulation or high-fat diet-feeding. 
DOI: 10.1111/jdi.12558


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